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In the realm of neurodegenerative disease, where definitive diagnostic tests are often lacking, diagnostic biomarkers play a pivotal role, not only in clinical practice but also as selection and stratification tools for clinical trials

[164] An investigation by the Wells Fargo board of directors, the report of which was released in April 2017, primarily blamed Stumpf, who it said had not responded to evidence of wrongdoing in the consumer services division, and Tolstedt, who was said to have knowingly set impossible sales goals and refused to respond when subordinates disagreed with them

doi: 10.1038/nature04139