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Ultimately, 17 studies met the inclusion criteria and were included in the analysis ( Table 2 )

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157 In the subsequent years, multicenter clinical investigations were carried out to prove the efficacy of UPA in the medical management of myomas

Under normoxic conditions, Nrf2 binds to Keap1 and continues to be inactivated by ubiquitination and degradation in the proteasome (Lu et al., 2017)