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In particular, TLR4 recruits the specific mediator MyD88, which triggers down-streaming signaling events for the NFkB phosphorylation and a consequent release of pro-inflammatory cytokines [33,34]

In addition, although the ratio of glycolysis to OXPHOS increases, in absolute terms, both glycolysis and oxidative phosphorylation are more active in cancer cells than in normal cells and the two processes coexist (30)

Dosing inconsistencies can significantly impact results

522 Combination strategies enhance ROS sensitivity through metabolic intervention
