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Effects of Ido1 activity include promotion of T cell- mediated tolerance and antimicrobial effects 154 and Ido1 might also act at the site of expression to decrease T-cell proliferation and survival, diminishing colonic inflammation and reducing disease severity 155

86 In cardiomyocytes, nicotine induced the same changes, with increased mitochondrial fission and decreased mitochondrial fusion, which not only induced excessive ROS, but also led to cell apoptosis due to excessive fission

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