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Although hotspot mutation analysis is widely used in clinical and research settings, it is characterized by some limitations that may reduce sensitivity and specificity in cancer diagnosis and prognosis: i) some cancer cells may lack detectable mutations due to intratumor heterogeneity
Unfortunately, the pharmacokinetic analysis of the compound revealed poor BBB permeability and a very low concentration in the brain [319]
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Hartman JH, Miller GP, Meyer JN
