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Challenges and future directions Combining MDSC checkpoint blockade with immune checkpoint inhibitors and adaptive cellular therapies offers a promising strategy to overcome immune suppression in the tumor microenvironment, especially in solid tumors

Glyoxylate and alanine can also be converted to glycine and pyruvate, respectively, via the action of the vitamin B6-dependent enzyme, alanineglyoxylate and serinepyruvate aminotransferase (encoded by the AGXT gene)