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Primary BAs are synthesized predominantly via hepatic 12-hydroxylation pathways involving CYP7A1 and CYP8B1, while secondary BAs derive from non-12-hydroxylated routes catalyzed by bacterial 7-dehydroxylase

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You may have a deficiency if you are vegan, dont eat enough B12 rich food, or if you have other health conditions which mean you are unable to absorb it properly, such as pernicious anaemia

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