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For instance, flavonoids found in fruits, herbs, cereals, nuts, stems, vegetables, seeds, and flowers are characterized by a benzopyran backbone consisting of two aromatic rings (A and B) and a heterocyclic C ring [138]

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Administration of the agonists CBD (TRPV2), GSK1702934A (TRPC3) and Yoda1 (Piezo1) immediately triggered strong, moderate and mild Ca 2+ influx, respectively, with comparable responses observed in WT and XKR8 KO BMNs, but probenecid (TRPV2) and GSK1016790A (TRPV4) did not (Extended Data Fig