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To your GP, to a therapist, to a trusted friend, to a helpline and to engage in psychological therapies like CBT and ACT for mental health support
Bortezomib, a proteasome inhibitor, caused significant neurotoxicity in patients with LN leading to the early termination of the trial (Table 1)
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Further studies showed that mitochondrial dihydroorotate dehydrogenase (DHODH) also runs in parallel with mitochondrial GPX4 to oxidify dihydroorotate to orotate and reduce panquinol to pantanol, thus acting as an anti-ferroptosis protein in the inner mitochondrial membrane [61]
