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Accessed 7 Aug 2023 Bezprozvanny I, Mattson MP

The GPX4-GSH axis The antioxidant function of GSH is largely executed through GPXs and PRDXs, which catalyze reductive detoxification of lipid peroxidation 93

Curcumin's potent inhibition of these enzymes helps to preserve joint integrity, reduce swelling, and significantly improve mobility and flexibility

This interference can affect enzyme activity, protein interactions, or structural stability, leading to misleading results
