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The force can damage the peptide structure through a process called mechanical denaturation

This may be important presenting that intestinal anastomosis healing requires improved abdominal aorta blood flow (25)

Otaka H, Murakami H, Nakayama H, Murabayashi M, Mizushiri S, Matsumura K, et al

they deliver radiofrequency energy through the skin surface via microneedles
