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concentrations greater than 60 M were not tested due to known cytotoxic effects in 3T3-L1 cells (see Figure 1)

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Sigmoidal dose-response curves and reliable estimates of IC 50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 3)

Missing doses disrupt the supply of nutrients needed for fat metabolism and energy production, resulting in slower results
