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28 Based on data from a phase 1 study and population pharmacokinetic modelling, AL 662 mg monthly, 882 mg every-6-week, and 1064 mg every-2-month regimens each produced plasma aripiprazole concentrations that were intermediate between those upper and lower concentrations 28 , 60 , 68 (Figure 5)

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The knowledge we will gain in the next few years from clinical studies will inform treatment guidelines with regard to which agents to use in whom and whether more aggressive approaches can slow the development of hyperglycaemia in those at high risk

MS and MS/MS spectra were collected on a high-resolution TripleTOF 5600 system (quadrupole-time-of-flight