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Additionally, HCG is contraindicated in cases of precocious puberty, as it may exacerbate early sexual development, especially in prepubertal males receiving it for cryptorchidism

A recent study combining intranasal insulin administration with a hyperinsulinemiceuglycemic clamp and functional MRI demonstrated that, in the follicular phase, insulin enhanced both whole-body glucose disposal and hypothalamic responsiveness [102]

The peptide also does not stimulate IGF-1 production, avoiding the growth-promoting and potentially mitogenic effects associated with IGF-1 elevation

2018;24(17):1837 to 1849
