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A known effector of PI3K, ARAP3, a GAP for small GTPases like RhoA and Arf6 has been shown to be a negative regulator of IgG IC-activated ROS production (Gambardella et al., 2013)

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Molecular characterization of GBM and diagnostic biomarkers Clinical grading of GBM GBM is classified as a World Health Organization (WHO) grade IV glioma, distinguished by aggressive behavior, high recurrence rates, and resistance to conventional therapies

Furthermore, suppression of IGF-1R activity has been proven to enhance radiosensitivity in cancer due to delayed double-strand break repair in cancer cells [41]