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Zhang Z, Wu H, Qi S, Tang Y, Qin C, Liu R, Zhang J, Cao Y, Gao X
A.YangL.CalingasanN.SmirnovaN.GaisinA.et al (2016)
In these contexts, astrocytes may shift from a neuroprotective role to one that exacerbates neuronal dysfunction, potentially due to downregulated expression of lactate dehydrogenase A (LDHA), a key glycolytic enzyme, which impairs lactate shuttling by inhibiting large conductance Ca 2+ activated potassium channel (BK channel)-mediated neuronal hyperpolarization (Yao et al., 2023)
Alternative Activation of Macrophages: Mechanism and Functions
