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PANs can be activated by mechanical and chemical signals, and thus transfer information on the status and content of the gut to the nervous (enteric and central), immune, and hormone system, allowing the integration of signals to promote gut and whole-body homeostasis (Rhee et al., 2009

Inhibition of cystathioninelyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS

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[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Han J., Weisbrod R.M., Shao D., Watanabe Y., Yin X., Bachschmid M.M., Seta F., Janssen-Heininger Y.M.W., Matsui R., Zang M., et al