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In vitro incubations Several parent drugs or precursors were incubated in pooled liver S9 fractions from CD1 mice , SpragueDawley rats , cynomolgus monkeys , or humans to generate specific metabolites for which no reference material was available (neither commercially nor internally)
But over the years reports have piled up about the occasional side effects of various antibiotics, including tendonitis, inner-ear problems and hearing loss, diarrhea, impaired kidney function, and other problems
10.1096/fj.02-0692fje 66 Falco-HolandaR
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