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The healthspan benefits of inhibiting ferroptosis confirm that healthspan improvement need not always require a change in global aging but can result from preventing a cause of frailty, raising an exciting conceptual prospect for therapeutic intervention
Zileuton, a specific inhibitor of ALOX5, decreased NaIO3-induced lipid peroxidation in RPE cells, as well as the degeneration of neuroretina and RPE monolayer cells (Lee et al., 2022)
Briefly, 2 L of this dilution was placed on a clean glass slide and a coverslip was mounted on top with double-sided tape serving as a spacer
