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It is specifically characterized by inflammation, demyelination, and neuronal loss and manifests with a range of neurological symptoms including numbness, tingling, vision impairment, cognitive impairment, and bladder and bowel dysfunction (Tafti et al., 2024)

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119 One exception to the general rule of TGF- as an inhibitor of adaptive immune responses is that TGF--activated SMADs cooperate with RORt to induce the T helper 17 (T H 17) phenotype