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Inhibition of the FSP1 pathway can weaken the protective effect of edaravone on TBI, suggesting that edaravone inhibits ferroptosis induced by injury in early TBI by activating FSP1 pathway

This raises the question of why activation of NRF2 through KEAP1 carbonylation (227, 228), which may further compromise cellular protection

DISCUSSION MTHFR (5,10-methylenetetrahydrofolate reductase) is an enzyme which catalyzes the conversion of 5,10-methylene-tetrahydrofolate (5,10-methylene-THF) to 5-methyl-tetrahydrofolate (5-methyl-THF)

Conclusions AX is a carotenoid with essentially no provitamin A activity in mammals and is found as a pigment in a wide variety of organisms, such as marine foods