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In spite of the aetiological bases of infertility, epigenetic alterations that occur on account of infertility treatment play a role in chronic longer-term diseases, involving differential methylation of genes vital for development and growth with longer-term implications pertaining to health (Reference Pisarska, Chan and Lawrenson28)

This section will provide an overview of adaptations in a wide array of neurochemical and neuromodulatory systems associated with alcohol dependence, with particular emphasis on their relationship to various signs and symptoms of the alcohol withdrawal syndrome, as well as their postulated role in underlying enhanced relapse susceptibility and perpetuation of excessive, unhealthy alcohol consumption

For the same reasons, female participants were advised to promptly inform the investigators in case of a suspected pregnancy, to be withdrawn from the study and to assess treatment continuation on a case-by-case basis

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