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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Therefore, in addition to cell-autonomous senescence induced via p53, p53-independent senescence can be triggered by extracellular TGF- 43

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39 Consistent with a role for ABCA1 in alleviating macrophage cholesterol burden in plaques, deletion of bone marrow ABCA1 accelerates atherosclerosis in mice, and humans heterozygous for loss of cholesterol efflux function in the ABCA1 gene are at increased CVD risk