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In addition, administration of muscimol (Lee et al., 2011) to microglia stimulated with lipopolysaccharide (LPS)/interferon-, the latter typically shows elevated levels following stroke (Kuric and Ruscher, 2014) significantly reduced the level of pro-inflammatory cytokines interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF)

Importantly, the integrity of the gut barrier and microbiota homeostasis is closely associated with systemic inflammation-a key driver of both CVD and cerebrovascular conditions

[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Zhang L., Hanigan M.H

doi: 10.1016/j.yrtph.2018.03.019 145