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Astrocytes and oligodendrocytes, which are highly metabolically active cells in the brain, may experience disrupted iron homeostasis, leading to impaired normal neural function, especially given their high sensitivity to oxidative stress

In 2011, researchers at Baylor College of Medicine led by Dr

Interestingly, suppressing the ER stress pathway PERK-ATF4-CHOP did not affect CHAC1 expression during ferroptosis ( As controlled induction of ferroptosis might prove a promising target for cancer research, various pharmacological substances have been tested for possibly inducing ferroptosis

PDAC) is highly resistant to chemotherapy