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In this article, we will give an overview of the current knowledge on the GSH metabolism of astrocytes, address how a high astrocytic GSH content can help to maintain brain functions, and discuss open questions and future perspectives of research on the functions of astrocytes in the GSH metabolism of the healthy and diseased brain

Additionally, folate, iron, and thyroid function should be evaluated, as deficiencies in these nutrients interact with B12 metabolism and can mask or amplify symptoms

doi: 10.1016/j.biochi.2020.02.005

Moreover, some antioxidants may also be of benefit in leukopenia and/or thrombocytopenia