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5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT) developed at the University of Texas Medical Branch by Neelakantan and colleagues as part of a medicinal-chemistry program targeting NNMT for metabolic-disease research

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Genetic variations: Certain glutathione S-transferase (GST) gene polymorphisms (e.g., GSTM1, GSTP1) increase autism risk and severity, especially when combined with prenatal exposures