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Activated TGF- inhibits the proliferation and migration of SMC, thus the inhibition of this regulatory effect of TGF- leads to accelerated blood vessel stenosis with concomitant enhancement of the atherogenic process

1991 (landmark Italian trial): A double-blind, placebo-controlled trial involving 130 patients with Alzheimer's disease demonstrated that one year of ALCAR treatment resulted in a slower rate of deterioration compared to placebo across 13 of 14 outcome measures, including significant improvements in the Blessed Dementia Scale, logical intelligence, verbal critical abilities, long-term verbal memory, and selective attention [5][17]