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At the regulatory level, aberrant activation of canonical pro-inflammatory pathways such as NF-B disrupts junctional complexes and induces cytokines, including IL-1, thereby amplifying inflammation and further compromising barrier integritya self-perpetuating cycle (Zeng et al., 2024)

10.1016/0047-6374(88)90099-1 85 OrentreichN.MatiasJ

Oxidative stress (OS) is considered to be involved in the development of many various diseases, e.g., cancer [29], diabetes [30], cardiovascular [21] or liver disorders [31], Alzheimers disease [32], psychological disturbances [33], pathological states affecting reproductive health [34,35,36] any many others

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