does aspirin deplete glutathione S-Acetyl by Celarity Molecular targets of aspirin and

Since vitamin B12 is water soluble, portions not metabolized by the body will be eliminated via urination

[4] [6] The direct delivery of ascorbic acid into the bloodstream allows for supraphysiological concentrations, which could have distinct biological effects, such as pro-oxidant activity in the presence of transition metals or selective cytotoxicity against certain malignant cells, although these applications remain under investigation and are not universally accepted as standard of care

So in the NAD+ vs Glutathione matchup for detox and immune support, glutathione clearly leads

Contribution of glutathione to the control of cellular redox homeostasis under toxic metal and metalloid stress