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This suggests that the oral supplement used in this study may be a reasonable alternative to subcutaneous injections of methyl-B12

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Antiepileptic Medications including: valproic acid (Depakene, Stavzor), carbamazepine (Carbatrol, Epitol, Tegretol, and others), and phenytoin (Dilantin) increase the catabolism rate of vitamin B6 vitamers, resulting in low plasma PLP concentrations and high homocysteine levels

doi:10.1016/j.gassur.2024.09.009 8
