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doi: 10.1002/mds.10473 16

Pro-inflammatory chemicals called cytokines (IL-6, TNF-) and prostaglandins contribute to fibroid growth and the heavy bleeding associated with them. Women with higher dietary inflammatory index scores show greater fibroid risk in observational data. Insulin and Insulin-Like Growth Factor Insulin resistance and hyperinsulinemia stimulate IGF-1, which acts on fibroid tissue growth receptors

doi: 10.1016/s0006-3223(00)01046-5

Broader solid tumor studies corroborate that pharmacological inhibition of CAF-mediated Gln synthesis disrupts tumor metabolic fitness, suggesting combinatorial targeting of tumoral and stromal glutamine metabolism, particularly through dual GLS1/ECM pathway inhibition, may offer promising therapeutic avenues for advanced prostate cancer (196)