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Therefore, the roles of acetate metabolism in mammals under normal physiological conditions remain to be established

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Front Pharmacol 14:1330910 Stockwell BR (2022) Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications

The target Cys must be located: (i) in an immediate vicinity to the NO source, (ii) within the protein I/LXCX 2 D/E motif specifically recognized by NOS, (iii) in a highly hydrophobic region created by the tertiary protein structure or membranes, (iv) in a proper microenvironment allowing thiolate anion formation [105]