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10.1097/01.TP.0000436927.08026.a8 Transplantation

Several mechanisms have been proposed to explain chronic hyperglycemia-induced nerve damage, such as intracellular accumulation of sorbitol, glycation reactions, and oxidative and nitrosative stress (reviewed in 69)

Fox, Mark Kennedy, Tiffany Silver-Brace, Jen C.C

Furthermore, injury results in the activation of phospholipases, such as PLC and cPLA 2 that leads to the generation of arachidonic acid, which in turn can increase membrane permeability and elevate levels of reactive oxygen species (ROS)
