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Description
Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism

It has produced successful results for a wide range of conditions: from psychological to neurological to cardiovascular disorders

It is typically administered to patients with conditions such as primary immunodeficiency, chronic inflammatory demyelinating polyneuropathy (CIDP), and immune thrombocytopenia (ITP)

In these cases, hydroxocobalamin or adenosylcobalamin may be better tolerated, as they provide B12 support without strongly stimulating methylation
