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Liposomes were stored at 4 C for up to 3 days prior to use

Integration of autosomal dominant AD patient CSF proteomics with brain tissue pathology identified SMOC1 as being abnormally elevated in the CSF nearly 30 years before the onset of cognitive symptoms, marking it as the earliest known biomarker of AD [200, 201]

Fresh lysozyme solution (10 mM Tris-HCl, 0.1 mM EDTA, 10 mg/ml lysozyme), 10% SDS (v/v) in RNAse-free water and lysis buffer (supplemented with 10 l of 2-mercaptoethanol per 1 ml of buffer) were prepared

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