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In view of the GO results, the Kyoto Encyclopedia of Genes and Genomes (KEGG) network enrichment analysis highlighted a greater effect on a metabolic pathway, glutathione metabolism (path:ko00480), which included upregulated Ggt1 and downregulated Anpep, in OVX rats (Figure 2F, and see Supplementary Tables S7)

Hence, additional signals are required and we will display later in this review that the weaning reaction is not solely happening because of the digestion of dietary fibers by gut microbes, but that it depends further on components in the breast milk, which delay the weaning reaction (19)

91 The pathway is initiated when cytokines, such as interleukin-6 (IL-6) bind to their receptors

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