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Moreover, transcriptomic analysis showed dysregulation in extracellular matrix pathways in SZ patient-derived migrating cINs, whereas sphere cINs from SZ patients showed dysregulation in immune pathways with HLA genes being mostly affected [112]

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Intermittent claudication in peripheral arterial disease In peripheral arterial disease, atherosclerosis of the arteries that supply the lower extremities may diminish blood flow to the point that the metabolic needs of exercising muscles are not sufficiently met, thereby leading to ischemic leg or hip pain known as claudication (see the page on Intermittent Claudication in Peripheral Arterial Disease) (63)