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In contrast, individuals with SLE have reduced diversity of gut microbiota, with a structural and functional disorder known as dysbiosis ( Firmicutes and Bacteroidetes together account for approximately 98% of the bacterial community, low F/B ratio is linked to gut microbiota dysbiosis, once more pointing to microbial imbalance as being key to SLE pathogenesis ( SLE patients are usually characterized by a condition called leaky gut, which is compromised integrity of the intestinal barrier

It was suggested to be a functional NMDA antagonist, thereby countering chronic alcohol exposure-induced increases in glutamate concentrations and the subsequent precipitation of a hyperglutamatergic state, which occur during alcohol withdrawal episodes (Dahchour et al., 1998)