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This work was also supported by Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0714 to H.T.), Chongqing Talents Plan for Young Talents (CQYC201905071 to S.P.), the strategic Priority Research Program of the Chinese Academy of Sciences (XDB39000000 to B.Z.), Youth Thousand Talents Plan (H.Z.), Shanghai Pujiang Program (16PJ1407400), and the National Key R&D Program of China (2019YFA0802804)

Mechanism-based treatments Mechanism-based treatments aim to target the underlying pathophysiological processes of DN to alleviate symptoms and prevent disease progression