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Description
In addition, in the mitochondria, it is a cofactor of methylmalonyl-CoA mutase, the enzyme that catalyses the reversible isomerization of methylmalonyl-CoA to succinyl-CoA, an essential intermediate in the citric acid cycle (TCA, Krebs cycle)
Elevated methylmalonic acid above 0.4 micromoles per liter confirms functional B12 deficiency even when serum levels appear adequate
Stern 2012
Sharifi-Rad, M
