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However, as we documented in our metabolic study on the hippocampus, animals with particular protection induced by preischemia, which manifest a general decrease in neuropathological signs of ischemic injury, showed a lower extent of changes in levels of glutamate, GABA, and glutamine, and a faster metabolic recovery comparable to non-protected animals (Baranovicova et al

However, the addition of progesterone counteracts the effects of oestradiol through its downstream metabolite, tetrahydroprogesterone, which enhances GABAergic inhibition 14

Therefore, the use of combination therapy is a viable path

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