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This POMC can leach out from the corticotrope cells via the constitutive secretory pathway, bringing about the high circulating levels [7, 25]
ASCO Abstract 2016
As a negative control, resistance mediated by genomic alterations that directly reactivate the MAPK pathway, such as through NRAS mutation (M249R) or BRAF alternative splicing (M395R, M397R) do not show differentiation changes (Figure 2A) (Nazarian et al., 2010)
