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Examples Repaglinide (Prandin) Dosage Initial: 0.52 mg before each meal, up to four times daily Maximum: 16 mg daily, 4 mg per dose Nateglinide (Starlix) Dosage Initial: 60120 mg before meals, up to three times daily Maximum: 360 mg daily, 120 mg per dose Possible side effects include: Hypoglycemia (lower risk than sulfonylureas) Weight gain Bile acid sequestrants Primary mechanism(s) of action Bile acid sequestrants were originally developed and approved to lower LDL-cholesterol

Reichel CM, Moussawi K, Do PH, Kalivas PW, See RE

Inflammation and peripheral nerve injury increase NGF expression and sensitise peripheral nociceptive terminals through the induction of gene expression in nociceptors [28]

Dietary supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle