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It does this by blocking the NF-B and MAP kinase pathways two key drivers of inflammatory signaling
J Biol Chem 276:3011130117
Incorporating analogous mitochondria directed GSH-sensing reporters into nanoplatforms would allow simultaneous readout and modulation of intramitochondrial redox status, enabling closed-loop theranostic schemes i.e
the modified nucleoside is selected from the group consisting of 5-bromo-2-O-methyluridine, 5-bromo-2-O-methyl-deoxyuridine, 5-bromo-2-deoxyuridine, 2-O-methylthymidine, 2-O-methylcytidine, 2-O-(2-methoxyethyl)thymidine and 8-oxo-7,8-dihydro-2-deoxyguanosine
