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Antioxidants It is well established that oxidative stress causes cataract development (19)

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Because these patients symptoms skull asymmetry, infantile spasms, dwarfism, brain atrophy, sensory impairments, and glycosylation abnormalities resembled type II congenital disorder of glycosylation (CDG), this study established a link between Mn deficiency and hereditary CDG, showing that mutations in SLC39A8 can decrease the supply of Mn to the Golgi enzyme -1-galactosyltransferase, which is essential for glycoprotein biosynthesis

Autophagy is controlled by several signalling pathways, including the PI3K/Akt/mTOR pathway, the AMPK pathway and the Beclin-1 complex