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Epigenetic modulation of gene expression by dietary isothiocyanates Despite the fact that most work on the cellular effects of ITC relates to their influence on detoxifying enzymes, recent data support the effect of these dietary compounds on the reactivation of epigenetically silenced genes in cancer cells, particularly through the inhibition of HDAC activity ( Reference Dashwood and Ho 52 )

Chromatin-modifying agents in anti-cancer therapy

Such recycling is believed to be triggered by conformational changes in PrP, which could occur in response to decreasing pH along the endocytic pathway and lead to the dissociation of Cu from PrP 29

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