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Ferroptosis has also been implicated in renal pathologies such as acute renal failure, renal ischemia-reperfusion injury (IRI) and DN (20-22)
These two proteins associate to form a hetero-oligomeric complex that facilitates pyruvate import into mitochondria

doi:10.18632/oncotarget.9100

In addition, catechol-O-methyltransferase (COMT) inhibitors such as entacapone and opicapone prolong the half-life of L-DOPA
