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In other brain areas, microglia regulate synapses and axons during the second and third postnatal week.[186] Developmental pruning is dependent on the localization of complement tags on synapses chosen for elimination.[235,236] Phagocytic receptors on the microglia (complement receptor 3-CR3/CD11b, CD18/MAC-1) localizes to synaptically enriched areas

Administration of a combinational topical preparation containing TXA and NCA with different mechanism of actions in melasma treatment would be promising and may result in synergistic clinical effectiveness

In summary, tweaking the reaction conditions to find a window in which the AON can be modified but not degraded was crucial to allow for this AON functionalisation protocol

Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001 China