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However, emerging evidence from studies indicates a significant association between long-term metformin use and vitamin B12 deficiency, with prevalence rates ranging from 6% to 66%
References : Deanna M
Therefore, any disruption of the microbiome in CKD can lead to intestinal barrier disruption and result in mucosal immune dysregulation, systemic immunological imbalance, and chronic inflammation, which lead to the progression of renal fibrosis, and the restoration of intestinal dysbiosis may improve this condition [124]
As is known, anti-GFAP is an astrocyte marker and anti-Iba-1 is a microglia marker
